Job Title: Grant Writer / Project Manager

The Grant Writer is responsible for the areas of new drug discovery and development grant proposal development. This individual researches grant opportunities available from local, state, federal, and philanthropic agencies and organizations. Duties and Responsibilities: (a)assures all grant proposals and contracts comply with Yalepharma guidelines and procedures (b)works with yalepharma management, faculty and staff to determine short and long-term funding objectives (c)assists in training yalepharma personnel with proposal preparation (d)work closely with the Yalepharma's Business Office and compliance offices to assure the accurate and timely expenditure of funds and adherence to program objectives. Minimum Requirements: (a)Bachelor's degree and six years of successful grant writing experience or Master's degree in a related field with two years of experience writing proposals to federal, state, and local agencies as well as foundations (c)experience within higher education desired (d)must possess excellent verbal and written communications skills (d)must show portfolio detailing grant proposal writing experience.

Job Title: Gov't Grant Writer

Masters Degree preferred. Bachelors Degree with three to five years experience of successful grant writing required (to include some federal grant writing). Ability to demonstrate a successful track record of funded proposals and knowledge of governmental grant/contract regulations. Ability to handle multiple projects and priorities successfully. Critical thinking skills, demonstrated initiative and creativity, independent judgment in problem solving. Ability to establish and adhere to projects and priorities successfully. Detail oriented. Flexible and the ability to work in a team environment. Exceptional interpersonal and customer service skills. Proficiency in current Windows environment and in Internet searches, database design and maintenance.

Job Title: Grant Writer

Masters Degree preferred. Bachelors Degree with three to five years experience of successful grant writing required (to include some federal grant writing). Ability to demonstrate a successful track record of funded proposals and knowledge of governmental grant/contract regulations. Ability to handle multiple projects and priorities successfully. Critical thinking skills, demonstrated initiative and creativity, independent judgment in problem solving. Ability to establish and adhere to projects and priorities successfully. Detail oriented. Flexible and the ability to work in a team environment. Exceptional interpersonal and customer service skills. Proficiency in current Windows environment and in Internet searches, database design and maintenance.

Job Title: Organic Chemist

We are currently seeking M.S. and B.S.-level organic chemists to join our Discovery Chemistry team. Conducting original research, you will be responsible for the preparation of organic target molecules and libraries for use in lead optimization and hit discovery programs. Expertise in multi-step organic synthesis, chromatographic purification and analysis, and spectral interpretation is required, as are excellent communication and interpersonal skills. Experience in automated combinatorial or parallel synthesis, aptitude with instrumentation, or advanced computer experience are also desirable.

Job Title: Cheminformatics Scientist

SUMMARY OF DUTIES: -Candidates will be responsible for the application of informatics and data mining techniques in the support of Discovery Research and Cheminformatics efforts and will be a key team member in providing scientists in other disciplines with critical tools and insight for decision making. -This will include consultation with individual scientists and working as a team with chemists, biologists, computational chemists and bioinformatics experts. -Communication and collaboration with statisticians and software developers in the development and deployment of novel expert and non-expert methods and tools. -Use of data visualization tools (Spotfire, JMP, etc). -Excellent verbal and written communication skills are required. -Preparation of technical reports, consultation reports and presentations for research projects are required. -Proactive project participation to anticipate and meet the needs of Discovery Research and Cheminformatics will be required.

MINIMUM QUALIFICATIONS: -Candidates should have a M.S. or Ph.D. in Chemistry, Biochemistry, Biophysics, Computational Chemistry or a related discipline with a strong background in Computer Science OR a M.S. or Ph.D. in Computer Science with a strong background in the natural sciences. -It is advantageous for candidates to have working knowledge of informatics systems and data mining/analysis techniques, SAR/QSAR medicinal chemistry analysis and design tools, statistics and the application of these approaches to problems of relevance in the pharmaceutical industry. -Experience with computer programming (perl, C or C++) and computational chemistry tools such as conformational analysis, docking, clustering would be valuable. -Candidates with at least 1-3 years experience in an industrial setting are preferred.

Job Title: Pharmaceutical formulation chemist

As a member of a biophysical characterization team you will be responsible for performing biophysical analyses of biopharmaceuticals to support early and commercial phase product development. Characterization of molecular conformation, association state, and aggregation in drug product and bulk drug bioproduct materials. This work involves close interactions with formulation, analytical, and bioprocess groups. Position Responsibilities: 1 Analysis of protein molecular conformation 2 Analysis of protein self association state 3 Thermodynamic analysis of protein stability e.g. folding/unfolding, calorimetry 4 Relating physical and conformational properties to properties of pharmaceutical importance 5 Therapeutic protein formulation, characterization and development.

JOB REQUIREMENTS: 1 Ph.D. in biochemistry, chemistry, pharmaceutical sciences, or a related field 2 Advanced proficiency with at least one technique associated with analysis of protein conformation, self-association, or aggregation. 3 Strong understanding of protein conformation and aggregation 4 Works well in a team environment under applicable cGMP laboratory requirements. Additional Preferences: 1 experience with thermodynamic methods to assess protein conformational stability. 2 experience conducting preformulation screening 3 experience using microcalorimetric methods for protein formulation development

Job Title: Quality Assurance Auditor

Quality Assurance Department Experience performing independent assessments on protocols, laboratory procedures, data, facilities, subcontractors/vendors, and reports, to determine the level of compliance with applicable domestic and foreign Good Laboratory Practice Regulations (GLP). Candidate must have strong interpersonal communication skills (oral and written) and the ability to prepare accurate, concise, and clear written reports. Bachelor s degree required (or Associate degree with relevant training and experience) and 2-3 years of auditing experience.

Job Title: Research Associates - Toxicology & Pathology Services

Significant Company growth has led to immediate openings in the following areas: Large Animal, Small Animal, Neuroscience, Pharmacokinetic, Histology, Necropsy, and Test Material Control Departments. You will be responsible for performing the technical functions needed to conduct toxicology, safety, and/or pharmacology studies placed at the laboratory, in compliance with Yale Pharmaceutical Research Institute SOP's, GLP's, and protocol requirements. College level science courses are highly desirable along with related experience in the research field. Bachelors in Biological Sciences field preferred. AALAS Certification Veterinary Anatomical Pathologist As a pathologist on our interdisciplinary team, you will oversee necropsies, make macroscopic observations, examine study animal tissues by light microscopy, analyze study data, write reports on findings, and interact with colleagues and clients. Applicants must have a D.V.M. or V.M.D. and be certified by the American College of Veterinary Pathologists. Three to five years of toxicological pathology experience is preferred.

Job Title: Histotechnologists

The candidates will be responsible for all aspects of routine histological procedures to include tissue trimming, embedding, microtomy, staining, coverslipping, and special stains. Ability to work well with others and capable of working under specific time constraints is essential.

Job Title: Group Leader Formulation & Drug Delivery Research

This comprises research into novel approaches to formulation and drug delivery, including the design and testing of formulation concepts up to the transition to advanced formulation development. Working with your team of scientists, which you will further expand, you will acquire the necessary skills and knowledge through collaboration with other disciplines within our global R&D organisation and with external partners.

You have a degree in pharmacy/pharmaceutics or a related discipline and hold a PhD, preferably in pharmaceutics or pharmaceutical technology. Industrial and/or significant post-doctoral experience is required. You have broad knowledge and experience of drug delivery and formulation technologies. An excellent background in biopharmaceutics and physical chemistry is essential. You are interested in innovative approaches and interdisciplinary teamwork, and have strong leadership and excellent communication skills.

Job Title: QA/QC Supervisor

BS or MS in Microbiology or Chemistry or equivalent in professional experience in relevant discipline if sufficient technical depth has been achieved and demonstrated. PhD in Microbiology or Chemistry preferred. Extensive experience in laboratory and quality systems, including laboratory and product investigations, method development and validation, documentation, compliance and operating in a high volume, rapid turnaround laboratory department. Minimum 4-6 years industry experience in a QA or QC environment. CGMP auditing skills. Minimum 2 years supervisory experience. Ability to analyze data, effectively summarize findings and draw conclusions; strong problem solving skills essential. Strong interpersonal skills. Solid team player able to function within team based organization. Ability to plan and execute multiple projects concurrently. Strong analytical and critical thinking skills. Strong verbal and written communication skills. Ability to work independently. Supervise the day to day activities of the QA, microbiology, chemistry and stability functions at the cytotoxic facility. Provide expertise to maintain/design/implement programs for compliance of all QA, microbiology and chemistry systems to company quality standards, cGMP, FDA, USP and other regulatory requirements. Develops Installation Qualification, Operation Qualification and Performance Qualification protocols for new laboratory equipment. Review and approve qualifications performed by junior staff. Performs qualifications as needed. Writes and approves all investigations, protocols and validations for laboratory and QA functions. Executes protocols as needed. Troubleshoots and solves problems with test methods and method transfers and equipment; implements resolutions. Institutes changes to methods and operations as appropriate. Plans, performs and documents tests and investigations in compliance with internal standards and external regulations. Trains personnel on new equipment, methods, and procedures. Maintains and improves proficiency of operations through training and education. Performs periodic reviews of USP, USP Supplements Pharm. Forum and other regulatory publications to ensure continued compliance with all regulatory agencies. Writes or revises SOPs as needed. Performs periodic productions and laboratory cGMP and safety audits, documenting findings. Defines and carries out corrective action plans as required. Writes audit plans and performs outside audits of contract laboratories and laboratory suppliers. Prepares audit reports of findings. Broadens understanding of laboratory techniques by keeping abreast with technical and professional literature and attending technical discussions both inside and outside the GSK community. Compiles trending reports. Carries out special projects as deemed appropriate by manager.

Job Title:Patent Agent

Patent Agent needed to assist Yalepharma's patent department. Position requires interaction with both legal and product development teams to develop scientific information, draft patent applications and prosecute patent filings before the Patent and Trademark Office. The hired agent will review and analyze technical documents such as art, laboratory notebooks, technical memoranda, deposition transcripts and file histories, perform patentability searches, prepare and file patent applications, and conduct all aspects of patent prosecution.

Qualifications

Registration to practice before the Patent and Trademark Office is required. Applicant must also possess a bachelors of science degree from an accredited four year college or university. No experience is necessary, however, preference will be given to applicants having experience with prosecuting a patent application, ranging from the preparation of invention disclosures, conducting patentability searches, preparing patent applications, and interacting with the USPTO.

Job Title: Analytical Chemist

Job Description

Under the direction of laboratory services management, performs analytical method transfer, optimization, development and validation. Performs these goals by developing protocols, conducting experiments using wet chemistry laboratory equipment, collecting and interpreting analytical data and writing reports in accordance with laboratory SOPs.

Job Summary

Performs analytical method transfer, optimization, and development/validation design and analytical methods development/validation of drug substances, drug product and residual testing, using guidelines from USP and ICH.
Performs US Compendial testing.
Performs routine sample processing and dosage form analysis using HPLC and UV-Vis analysis equipment, Dissolution, pH, etc.

Requirements

Bachelor’s degree in Chemistry or related scientific field with at least 2 years of analytical chemical experience. Pharmaceutical laboratory experience preferred. Experience with laboratory instrumentation (i.e., HPLC, Disso., FTIR and TOC). Experience with SEC, SDS-PAGE and IEX preferred. Effective written and verbal communication with skills and the ability to interact effectively with staff members from multiple levels and departments. The candidate must be a self-starter.